Ontology highlight
ABSTRACT:
SUBMITTER: Ng M
PROVIDER: S-EPMC4252868 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ng Melinda M Ndungo Esther E Jangra Rohit K RK Cai Yingyun Y Postnikova Elena E Radoshitzky Sheli R SR Dye John M JM Ramírez de Arellano Eva E Negredo Ana A Palacios Gustavo G Kuhn Jens H JH Chandran Kartik K
Virology 20141011
Lloviu virus (LLOV), a phylogenetically divergent filovirus, is the proposed etiologic agent of die-offs of Schreibers's long-fingered bats (Miniopterus schreibersii) in western Europe. Studies of LLOV remain limited because the infectious agent has not yet been isolated. Here, we generated a recombinant vesicular stomatitis virus expressing the LLOV spike glycoprotein (GP) and used it to show that LLOV GP resembles other filovirus GP proteins in structure and function. LLOV GP must be cleaved b ...[more]