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Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis.

ABSTRACT: Cell-to-cell communication is a fundamental mechanism for coordinating developmental and physiological events in multicellular organisms. Heterotrimeric G proteins are key molecules that transmit extracellular signals; similarly, CLAVATA signaling is a crucial regulator in plant development. Here, we show that Arabidopsis thaliana G? mutants exhibit an enlarged stem cell region, which is similar to that of clavata mutants. Our genetic and cell biological analyses suggest that the G protein beta-subunit1 AGB1 and RPK2, one of the major CLV3 peptide hormone receptors, work synergistically in stem cell homeostasis through their physical interactions. We propose that AGB1 and RPK2 compose a signaling module to facilitate meristem development.

SUBMITTER: Ishida T

PROVIDER: S-EPMC4253494 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis.

Ishida Takashi T Tabata Ryo R Yamada Masashi M Aida Mitsuhiro M Mitsumasu Kanako K Fujiwara Masayuki M Yamaguchi Katsushi K Shigenobu Shuji S Higuchi Masayuki M Tsuji Hiroyuki H Shimamoto Ko K Hasebe Mitsuyasu M Fukuda Hiroo H Sawa Shinichiro S

EMBO reports 20140926 11

Cell-to-cell communication is a fundamental mechanism for coordinating developmental and physiological events in multicellular organisms. Heterotrimeric G proteins are key molecules that transmit extracellular signals; similarly, CLAVATA signaling is a crucial regulator in plant development. Here, we show that Arabidopsis thaliana Gβ mutants exhibit an enlarged stem cell region, which is similar to that of clavata mutants. Our genetic and cell biological analyses suggest that the G protein beta- ...[more]

PMID: 25260844

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Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis.

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