Human structural proteome-wide characterization of Cyclosporine A targets.
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ABSTRACT:
SUBMITTER: Hu G
PROVIDER: S-EPMC4253830 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Human structural proteome-wide characterization of Cyclosporine A targets.
Hu Gang G Wang Kui K Groenendyk Jody J Barakat Khaled K Mizianty Marcin J MJ Ruan Jishou J Michalak Marek M Kurgan Lukasz L
Bioinformatics (Oxford, England) 20140828 24
<h4>Motivation</h4>Off-target interactions of a popular immunosuppressant Cyclosporine A (CSA) with several proteins besides its molecular target, cyclophilin A, are implicated in the activation of signaling pathways that lead to numerous side effects of this drug.<h4>Results</h4>Using structural human proteome and a novel algorithm for inverse ligand binding prediction, ILbind, we determined a comprehensive set of 100+ putative partners of CSA. We empirically show that predictive quality of ILb ...[more]
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