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T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells.

ABSTRACT: CD8 tissue-resident memory T (T(RM)) cells provide efficient local control of viral infection, but the role of CD4 T(RM) is less clear. Here, by using parabiotic mice, we show that a preexisting pool of CD4 T(RM) cells in the genital mucosa was required for full protection from a lethal herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of macrophages maintained vaginal CD4 T(RM) in memory lymphocyte clusters (MLCs), independently of circulating memory T cells. CD4 T(RM) cells within the MLCs were enriched in clones that expanded in response to HSV-2. Our results highlight the need for vaccine strategies that enable establishment of T(RM) cells for protection from a sexually transmitted virus and provide insights as to how such a pool might be established.

SUBMITTER: Iijima N

PROVIDER: S-EPMC4254703 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells.

Iijima Norifumi N Iwasaki Akiko A

Science (New York, N.Y.) 20140828 6205

CD8 tissue-resident memory T (T(RM)) cells provide efficient local control of viral infection, but the role of CD4 T(RM) is less clear. Here, by using parabiotic mice, we show that a preexisting pool of CD4 T(RM) cells in the genital mucosa was required for full protection from a lethal herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of macrophages maintained vaginal CD4 T(RM) in memory lymphocyte clusters (MLCs), independently of circulating memory T cells. CD4 ...[more]

PMID: 25170048

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