Ontology highlight
ABSTRACT:
SUBMITTER: Sliogeryte K
PROVIDER: S-EPMC4255193 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Sliogeryte Kristina K Thorpe Stephen D SD Lee David A DA Botto Lorenzo L Knight Martin M MM
Scientific reports 20141204
This study examines how differentiation of human mesenchymal stem cells regulates the interaction between the cell membrane and the actin cortex controlling cell behavior. Micropipette aspiration was used to measure the pressure required for membrane-cortex detachment which increased from 0.15 kPa in stem cells to 0.71 kPa following chondrogenic differentiation. This effect was associated with reduced susceptibility to mechanical and osmotic bleb formation, reduced migration and an increase in c ...[more]