Ontology highlight
ABSTRACT:
SUBMITTER: Goodrich JK
PROVIDER: S-EPMC4255478 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Goodrich Julia K JK Waters Jillian L JL Poole Angela C AC Sutter Jessica L JL Koren Omry O Blekhman Ran R Beaumont Michelle M Van Treuren William W Knight Rob R Bell Jordana T JT Spector Timothy D TD Clark Andrew G AG Ley Ruth E RE
Cell 20141101 4
Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear. Here, we compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs. We identified many microbial taxa whose abundances were influenced by host genetics. The most heritable taxon, the family Christensenellaceae, formed a co-occurrence network w ...[more]