Bayesian inference of shared recombination hotspots between humans and chimpanzees.

ABSTRACT: Recombination generates variation and facilitates evolution. Recombination (or lack thereof) also contributes to human genetic disease. Methods for mapping genes influencing complex genetic diseases via association rely on linkage disequilibrium (LD) in human populations, which is influenced by rates of recombination across the genome. Comparative population genomic analyses of recombination using related primate species can identify factors influencing rates of recombination in humans. Such studies can indicate how variable hotspots for recombination may be both among individuals (or populations) and over evolutionary timescales. Previous studies have suggested that locations of recombination hotspots are not conserved between humans and chimpanzees. We made use of the data sets from rece

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4256775 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature