Dataset Information

Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.

ABSTRACT: BACKGROUND:Interleukin-4(IL-4) is a critical inflammatory cytokine and has been involved in pathogenesis of cancer. To date, several studies have investigated the association between IL-4 intron 3 variable number of tandem repeats (VNTR) polymorphism and cancer risk in humans; however, the results remain controversial. We performed this meta-analysis to find a more conclusive association between this polymorphism and cancer risk. METHODS:Eight eligible case-control studies were identified through searching electronic databases, including 1583 cases and 1638 controls. Odds ratio (OR) and corresponding 95% confidence interval (CI) were used to estimate the strength of the association. RESULTS:The results of overall analyses indicated that the variant RP2 allele was associated with a decreased cancer risk compared with the RP1 allele (RP2/RP2 vs. RP1/RP1, OR?=?0.64, 95% CI?=?0.44-0.94; RP2/RP2 vs. RP1/RP1?+?RP1/RP2, OR?=?0.75, 95% CI?=?0.60-0.92; RP2 vs. RP1, OR?=?0.72, 95% CI?=?0.56-0.92). In subgroup analyses stratified by ethnicity, there was evidence in the Asian population for an association between this polymorphism and cancer risk (RP2/RP2 vs. RP1/RP1?+?RP1/RP2, OR?=?0.79, 95% CI?=?0.63-0.99; RP2 vs. RP1, OR?=?0.77, 95% CI?=?0.61-0.97). CONCLUSIONS:IL-4 intron 3 VNTR polymorphism could influence the risk of human cancer. Due to the limitations of this meta-analysis, further well-designed and functional researches should be performed to validate our results.

SUBMITTER: Duan Y

PROVIDER: S-EPMC4258052 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.

Duan Yin Y Pan Chi C Shi Jinan J Chen Hailong H Zhang Suzhan S

Cancer cell international 20141130 1

<h4>Background</h4>Interleukin-4(IL-4) is a critical inflammatory cytokine and has been involved in pathogenesis of cancer. To date, several studies have investigated the association between IL-4 intron 3 variable number of tandem repeats (VNTR) polymorphism and cancer risk in humans; however, the results remain controversial. We performed this meta-analysis to find a more conclusive association between this polymorphism and cancer risk.<h4>Methods</h4>Eight eligible case-control studies were id ...[more]

PMID: 25484626

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Project description:The results of published studies which examined the association between variable number tandem repeat (VNTR) polymorphism of interleukin-1 receptor antagonist (IL-1RN) and ischemic stroke (IS) are conflicting. Thus, we performed a meta-analysis to examine the potential association between IL-1RN VNTR polymorphism and IS risk.A systematic literature search of PubMed, Embase, Medline, Web of Science, Cochrane Library, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, CQVIP, and WANFANG Database identified 10 studies with 2331 cases and 3335 controls. The pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated to evaluate the strength of the association. Subgroup analysis and meta-regression analysis were used to investigate the potential sources of heterogeneity. Begg funnel plots were used to explore the publication bias.In this study, no enough proof was found to prove the association between IL-1RN 86-bp VNTR polymorphism and IS risk with random-effects model in the homozygous model (1/1 vs 2/2, OR = 0.97, 95% CI?=?0.50-1.87, Pheterogeneity?=?.00), the heterozygous model (1/2 vs 2/2, OR?=?0.64, 95% CI?=?0.41-1.01, Pheterogeneity?=?.10), the dominant model (1/1?+?1/2 vs 2/2, OR?=?0.85, 95% CI?=?0.51-1.42, Pheterogeneity?=?.02), the recessive model (1/1 vs 1/2?+?2/2, OR?=?0.69, 95% CI?=?0.46-1.03, Pheterogeneity?=?.00), and allelic model (1 vs 2, OR?=?1.24, 95% CI?=?0.89-1.74, Pheterogeneity?=?.00). A marginally significant negative association was observed between IL-1RN 86-bp VNTR polymorphism and IS risk in the heterozygous model in the fixed-effects model (1/2 vs 2/2, OR?=?0.71, 95% CI?=?0.53-0.95, Pheterogeneity?=?.10). In subgroup analyses, similar association was found in the group whose control size was lower than 300.In conclusion, our results suggested that there was no sufficient evidence to support the association between IL-1RN 86-bp VNTR polymorphism and IS. Further large epidemiologic studies need to be done to confirm these findings.

Project description:Asthma is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the polymorphism of IL-1? -511C/T and IL-1RA genes in relation to asthma susceptibility in different populations. However, the results of individual studies have been inconsistent. Accordingly, we conducted a comprehensive meta-analysis to investigate the association between the IL-1? -511C/T and IL-1RA polymorphism and asthma risk.Data were collected from the following electronic databases: Pub Med, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), ISI Web of Knowledge, and Google Scholar Search databases with the last report up to July 2013. Finally, 15 studies were included in our meta-analysis. We summarized the data on the association between IL-1? -511C/T and IL-1RA polymorphism and risk of asthma in the overall population and performed subgroup analyses by ethnicity, mean of age, and source of controls. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between IL-1? -511C/T and IL-1RA polymorphism and asthma risk. Statistical analysis was performed with Review Manager 5.1.A total of 15 case-control studies were included in the meta-analysis of IL-1? -511C/T (1,385 cases and 1,964 controls) and IL-1RA (2,800 cases and 6,359 controls) genotypes. No association was found between IL-1? -511C/T polymorphism and asthma risk (dominant model: OR = 1.11, 95% CI: 0.99-1.25, P = 0.07, P Heterogeneity = 0.06; recessive model: OR = 1.04, 95% CI: 0.91-1.20, P = 0.55, P Heterogeneity = 0.11). Subgroup analysis based on ethnicity (Asian and Caucasian), source of controls (population-based controls and hospital-based controls), and mean of age (adulthood and childhood) did not present any significant association. The overall results showed that the IL-1RA polymorphism was related to an increased risk of asthma (homozygote model: OR = 1.32, 95% CI: 1.12-1.56, P = 0.0009, P Heterogeneity = 0.87; recessive model: OR = 1.39, 95% CI: 1.18-1.63, P = 0.0001, P Heterogeneity = 0.82). Similar results were found in the subgroup analyses by ethnicity, mean of age, and source of controls. Sensitivity analysis did not perturb the results.This meta-analysis provided strong evidence that the IL-1RA polymorphism was a risk factor of asthma, especially in Caucasian populations. However, no association was found for IL-1? -511C/T genotype carriers. Larger scale studies are needed for confirmation.

Dataset Information

Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.

Publications

Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.

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