Canonical structures of short CDR-L3 in antibodies.
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ABSTRACT:
SUBMITTER: Teplyakov A
PROVIDER: S-EPMC4260120 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Canonical structures of short CDR-L3 in antibodies.
Teplyakov Alexey A Gilliland Gary L GL
Proteins 20140416 8
Despite sequence diversity, five out of six hypervariable loops in antibodies assume a limited number of conformations called canonical structures. Their correct identification is essential for successful prediction of antibody structure. This in turn requires regular updates of the classification of canonical structures to match the expanding experimental database. Antibodies with the eight-residue CDR-L3 represent the second most common type of antibodies after those with the nine-residue CDR- ...[more]
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