Ontology highlight
ABSTRACT:
SUBMITTER: Nowak J
PROVIDER: S-EPMC4966832 | biostudies-literature | 2016 May-Jun
REPOSITORIES: biostudies-literature
Nowak Jaroslaw J Baker Terry T Georges Guy G Kelm Sebastian S Klostermann Stefan S Shi Jiye J Sridharan Sudharsan S Deane Charlotte M CM
mAbs 20160501 4
Complementarity-determining regions (CDRs) are antibody loops that make up the antigen binding site. Here, we show that all CDR types have structurally similar loops of different lengths. Based on these findings, we created length-independent canonical classes for the non-H3 CDRs. Our length variable structural clusters show strong sequence patterns suggesting either that they evolved from the same original structure or result from some form of convergence. We find that our length-independent me ...[more]