Ontology highlight
ABSTRACT:
SUBMITTER: Hather G
PROVIDER: S-EPMC4264612 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hather Gregory G Liu Ray R Bandi Syamala S Mettetal Jerome J Manfredi Mark M Shyu Wen-Chyi WC Donelan Jill J Chakravarty Arijit A
Cancer informatics 20141209 Suppl 4
Human tumor xenograft studies are the primary means to evaluate the biological activity of anticancer agents in late-stage preclinical drug discovery. The variability in the growth rate of human tumors established in mice and the small sample sizes make rigorous statistical analysis critical. The most commonly used summary of antitumor activity for these studies is the T/C ratio. However, alternative methods based on growth rate modeling can be used. Here, we describe a summary metric called the ...[more]