Ontology highlight
ABSTRACT:
SUBMITTER: Rasmussen MA
PROVIDER: S-EPMC4266010 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Rasmussen Mikkel A MA Holst Bjørn B Tümer Zeynep Z Johnsen Mads G MG Zhou Shuling S Stummann Tina C TC Hyttel Poul P Clausen Christian C
Stem cell reports 20140821 3
The discovery of human-induced pluripotent stem cells (iPSCs) has sparked great interest in the potential treatment of patients with their own in vitro differentiated cells. Recently, knockout of the Tumor Protein 53 (p53) gene was reported to facilitate reprogramming but unfortunately also led to genomic instability. Here, we report that transient suppression of p53 during nonintegrative reprogramming of human fibroblasts leads to a significant increase in expression of pluripotency markers and ...[more]