Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC4288576 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Science China. Life sciences 20140816 9
Dopaminergic (DA) neuron-like cells obtained through direct reprogramming of primary human fibroblasts offer exciting opportunities for treatment of Parkinson's disease. A significant obstacle is the low efficiency of conversion during the reprogramming process. Here, we demonstrate that the suppression of p53 significantly enhances the efficiency of transcription factor-mediated conversion of human fibroblasts into functional dopaminergic neurons. In particular, blocking p53 activity using a do ...[more]