Ontology highlight
ABSTRACT:
SUBMITTER: Zimdahl B
PROVIDER: S-EPMC4267534 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Nature genetics 20140202 3
Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein-binding protein Lis1 is critically required for hematopoietic stem cell function and leukemogenesis. Conditional deletion of Lis1 (also known as Pafah1b1) in the hematopoietic system led to a severe bloodless phenotype, depletion of the stem cell pool and embryonic lethality. Further, rea ...[more]