Ontology highlight
ABSTRACT:
SUBMITTER: Hitomi M
PROVIDER: S-EPMC7934841 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Hitomi Masahiro M Chumakova Anastasia P AP Silver Daniel J DJ Knudsen Arnon M AM Pontius W Dean WD Murphy Stephanie S Anand Neha N Kristensen Bjarne W BW Lathia Justin D JD
JCI insight 20210208 3
Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therapy, yet the functional consequences of these division modes remain to be determined. Using a fluorescent reporter for cell surface receptor distribution during mitosis, we found that ACD generated a daughter cell with enhanced therapeutic resistance a ...[more]