Ontology highlight
ABSTRACT:
SUBMITTER: Osborne MJ
PROVIDER: S-EPMC4269245 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Osborne Michael J MJ Borden Katherine L B KL
Immunological reviews 20150101 1
The eukaryotic translation initiation factor eIF4E is a potent oncogene. Although eIF4E has traditional roles in translation initiation in the cytoplasm, it is also found in the nucleus, suggesting that it has activities beyond its role in protein synthesis. The road less traveled has been taken to study these nuclear activities and to understand their contribution to the oncogenic potential of eIF4E. The molecular features and biological pathways underpinning eIF4E's nuclear mRNA export are des ...[more]