Ontology highlight
ABSTRACT:
SUBMITTER: Tam JM
PROVIDER: S-EPMC4271056 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20140519 11
Autophagy has been postulated to play role in mammalian host defense against fungal pathogens, although the molecular details remain unclear. Here, we show that primary macrophages deficient in the autophagic factor LC3 demonstrate diminished fungicidal activity but increased cytokine production in response to Candida albicans stimulation. LC3 recruitment to fungal phagosomes requires activation of the fungal pattern receptor dectin-1. LC3 recruitment to the phagosome also requires Syk signaling ...[more]