Ontology highlight
ABSTRACT:
SUBMITTER: Heinsbroek SE
PROVIDER: S-EPMC3005358 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Heinsbroek Sigrid E M SE Kamen Lynn A LA Taylor Philip R PR Brown Gordon D GD Swanson Joel J Gordon Siamon S
Journal of innate immunity 20081112 3
Candida albicans is a dimorphic yeast that enters macrophages (Mphi) via the beta-glucan receptor dectin-1. Phagocytosis of C. albicans is characterized by actin polymerization, Syk kinase activation and rapid acquisition of phagolysosomal markers. In mice, C. albicans are able to resist the harsh environment of the phagosome and form pseudohyphae inside the phagolysosomal compartment, eventually extending from the Mphi. In this study, we investigated these unique C. albicans phagosomes and foun ...[more]