Ontology highlight
ABSTRACT:
SUBMITTER: Pulk A
PROVIDER: S-EPMC4274944 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130601 6140
Protein synthesis by the ribosome requires the translocation of transfer RNAs and messenger RNA by one codon after each peptide bond is formed, a reaction that requires ribosomal subunit rotation and is catalyzed by the guanosine triphosphatase (GTPase) elongation factor G (EF-G). We determined 3 angstrom resolution x-ray crystal structures of EF-G complexed with a nonhydrolyzable guanosine 5'-triphosphate (GTP) analog and bound to the Escherichia coli ribosome in different states of ribosomal s ...[more]