Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart.
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ABSTRACT:
SUBMITTER: Tian X
PROVIDER: S-EPMC4275002 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart.
Tian Xueying X Hu Tianyuan T Zhang Hui H He Lingjuan L Huang Xiuzhen X Liu Qiaozhen Q Yu Wei W He Liang L Yang Zhen Z Yan Yan Y Yang Xiao X Zhong Tao P TP Pu William T WT Zhou Bin B
Science (New York, N.Y.) 20140701 6192
The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within th ...[more]
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