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MicroRNA-503 acts as a tumor suppressor in osteosarcoma by targeting L1CAM.


ABSTRACT: Deregulated microRNAs and their roles in tumorigenesis have attracted much attention in recent years. Although miR-503 was shown to be important in tumorigenesis, its role in osteosarcoma remains unknown. In this study, we focused on the expression and mechanisms of miR-503 in osteosarcoma development. We found that miR-503 was down-regulated in osteosarcoma cell lines and primary tumor samples, and the restoration of miR-503 reduced cell proliferation, migration and invasion. Low level of miR-503 in patients with osteosarcoma was associated with considerably shortened disease-free survival. Furthermore, bioinformatic prediction and experimental validation revealed that the anti-tumor effect of miR-503 was probably exerted through targeting and repressing of L1CAM expression. L1CAM was up-regulated in osteosarcoma cell lines and primary tumor samples and the expression level of L1CAM were negatively correlated with miR-503 levels in osteosarcoma tissues. Collectively, our data identify the important roles of miR-503 in osteosarcoma pathogenesis, indicating its potential application in cancer therapy.

SUBMITTER: Chong Y 

PROVIDER: S-EPMC4275157 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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MicroRNA-503 acts as a tumor suppressor in osteosarcoma by targeting L1CAM.

Chong Yang Y   Zhang Jie J   Guo Xinzhen X   Li Guojun G   Zhang Shiqian S   Li Chao C   Jiao Zhijian Z   Shao Ming M  

PloS one 20141223 12


Deregulated microRNAs and their roles in tumorigenesis have attracted much attention in recent years. Although miR-503 was shown to be important in tumorigenesis, its role in osteosarcoma remains unknown. In this study, we focused on the expression and mechanisms of miR-503 in osteosarcoma development. We found that miR-503 was down-regulated in osteosarcoma cell lines and primary tumor samples, and the restoration of miR-503 reduced cell proliferation, migration and invasion. Low level of miR-5  ...[more]

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