Ontology highlight
ABSTRACT:
SUBMITTER: Veys C
PROVIDER: S-EPMC10501397 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Veys Clément C Boulouard Flavie F Benmoussa Abderrahim A Jammes Manon M Brotin Emilie E Rédini Françoise F Poulain Laurent L Gruchy Nicolas N Denoyelle Christophe C Legendre Florence F Galera Philippe P
Frontiers in oncology 20230831
Chondrosarcomas and osteosarcomas are malignant bone tumors with a poor prognosis when unresectable or metastasized. Moreover, radiotherapy and chemotherapy could be ineffective. MiRNAs represent an alternative therapeutic approach. Based on high-throughput functional screening, we identified four miRNAs with a potential antiproliferative effect on SW1353 chondrosarcoma cells. Individual functional validations were then performed in SW1353 cells, as well as in three osteosarcoma cell lines. The ...[more]