Ontology highlight
ABSTRACT:
SUBMITTER: Di Sante G
PROVIDER: S-EPMC4278247 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Di Sante Gabriele G Pestell Timothy G TG Casimiro Mathew C MC Bisetto Sara S Powell Michael J MJ Lisanti Michael P MP Cordon-Cardo Carlos C Castillo-Martin Mireia M Bonal Dennis M DM Debattisti Valentina V Chen Ke K Wang Liping L He Xiaohong X McBurney Michael W MW Pestell Richard G RG
The American journal of pathology 20150101 1
Prostatic intraepithelial neoplasia is a precursor to prostate cancer. Herein, deletion of the NAD(+)-dependent histone deacetylase Sirt1 induced histological features of prostatic intraepithelial neoplasia at 7 months of age; these features were associated with increased cell proliferation and enhanced mitophagy. In human prostate cancer, lower Sirt1 expression in the luminal epithelium was associated with poor prognosis. Genetic deletion of Sirt1 increased mitochondrial superoxide dismutase 2 ...[more]