Ontology highlight
ABSTRACT:
SUBMITTER: Pascal LE
PROVIDER: S-EPMC7076293 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pascal Laura E LE Rigatti Lora H LH Ai Junkui J Zhang Aiyuan A Zhou Jianhua J Nelson Joel B JB Wang Zhou Z
American journal of clinical and experimental urology 20200225 1
Defining the cell of origin for prostatic carcinogenesis is fundamentally important for understanding the mechanisms leading to prostate cancer. Lineage tracing studies have demonstrated that luminal epithelial cells are capable of self-replication in multiple organs, including the adult murine prostate, and cell of prostate cancer origin studies have shown that while both the luminal and basal murine prostate epithelial cells are capable of neoplastic transformation, luminal cells are more effi ...[more]