Ontology highlight
ABSTRACT:
SUBMITTER: Caballero-Lima D
PROVIDER: S-EPMC4278529 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Caballero-Lima David D Hautbergue Guillaume M GM Wilson Stuart A SA Sudbery Peter E PE
Molecular microbiology 20141014 4
Candida albicans hyphae grow in a highly polarized fashion from their tips. This polarized growth requires the continuous delivery of secretory vesicles to the tip region. Vesicle delivery depends on Sec2p, the Guanine Exchange Factor (GEF) for the Rab GTPase Sec4p. GTP bound Sec4p is required for the transit of secretory vesicles from the trans-Golgi to sites of polarized growth. We previously showed that phosphorylation of Sec2p at residue S584 was necessary for Sec2p to support hyphal, but no ...[more]