Ontology highlight
ABSTRACT:
SUBMITTER: Houssen WE
PROVIDER: S-EPMC4282754 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Houssen Wael E WE Bent Andrew F AF McEwan Andrew R AR Pieiller Nathalie N Tabudravu Jioji J Koehnke Jesko J Mann Greg G Adaba Rosemary I RI Thomas Louise L Hawas Usama W UW Liu Huanting H Schwarz-Linek Ulrich U Smith Margaret C M MC Naismith James H JH Jaspars Marcel M
Angewandte Chemie (International ed. in English) 20141021 51
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine-derived enzymes and substrates obtained from a family of ribosomally produced and post-translationally modified peptides called the cyanobactins. The substrate precursor peptide is engineered to have a non-native protease cleavage site that can be rapi ...[more]