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Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.

ABSTRACT: Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression increases in response to epidermal barrier challenges. In this study, we report the generation of Calm4 knockout mice and provide evidence that Calm4 is dispensable for epidermal barrier formation, maintenance and repair.

SUBMITTER: Lessard JC

PROVIDER: S-EPMC4289410 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.

Lessard Juliane C JC Kalinin Alexandr A Bible Paul W PW Morasso Maria I MI

Experimental dermatology 20141120 1

Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression increases in response to epidermal barrier challenges. In this study, we report the generation of Calm4 knockout mice and provide evidence that Calm4 is dispensable for epidermal barrie ...[more]

PMID: 25316000

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