Endo-selective Pd-catalyzed silyl methyl Heck reaction.
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ABSTRACT: A palladium (Pd)-catalyzed endo-selective Heck reaction of iodomethylsilyl ethers of phenols and aliphatic alkenols has been developed. Mechanistic studies reveal that this silyl methyl Heck reaction operates via a hybrid Pd-radical process and that the silicon atom is crucial for the observed endo selectivity. The obtained allylic silyloxycycles were further oxidized into (Z)-alkenyldiols.
SUBMITTER: Parasram M
PROVIDER: S-EPMC4291758 | biostudies-literature |
REPOSITORIES: biostudies-literature
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