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SecureMA: protecting participant privacy in genetic association meta-analysis.


ABSTRACT: Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access to data.We introduce a novel cryptographic strategy to securely perform meta-analysis for genetic association studies in large consortia. Our methodology is useful for supporting joint studies among disparate data sites, where privacy or confidentiality is of concern. We validate our method using three multisite association studies. Our research shows that genetic associations can be analyzed efficiently and accurately across substudy sites, without leaking information on individual participants and site-level association summaries.Our software for secure meta-analysis of genetic association studies, SecureMA, is publicly available at http://github.com/XieConnect/SecureMA. Our customized secure computation framework is also publicly available at http://github.com/XieConnect/CircuitService.

SUBMITTER: Xie W 

PROVIDER: S-EPMC4296153 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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SecureMA: protecting participant privacy in genetic association meta-analysis.

Xie Wei W   Kantarcioglu Murat M   Bush William S WS   Crawford Dana D   Denny Joshua C JC   Heatherly Raymond R   Malin Bradley A BA  

Bioinformatics (Oxford, England) 20140821 23


<h4>Motivation</h4>Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access to data.<h4>Results</h4>We introduce a novel cryptographic strategy to securely perform meta-analysis for genetic association studies in large consortia. Our methodology is u  ...[more]

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