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X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes.


ABSTRACT: Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.

SUBMITTER: Naczynski DJ 

PROVIDER: S-EPMC4296927 | biostudies-literature |

REPOSITORIES: biostudies-literature

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