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Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates.

ABSTRACT: Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.

SUBMITTER: Shin D

PROVIDER: S-EPMC4298453 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates.

Shin Dongwon D Lönn Peter P Dowdy Steven F SF Tor Yitzhak Y

Chemical communications (Cambridge, England) 20150101 9

Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery. ...[more]

PMID: 25500944

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