Ontology highlight
ABSTRACT:
SUBMITTER: Chasman D
PROVIDER: S-EPMC4299600 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Molecular systems biology 20141119
Stressed cells coordinate a multi-faceted response spanning many levels of physiology. Yet knowledge of the complete stress-activated regulatory network as well as design principles for signal integration remains incomplete. We developed an experimental and computational approach to integrate available protein interaction data with gene fitness contributions, mutant transcriptome profiles, and phospho-proteome changes in cells responding to salt stress, to infer the salt-responsive signaling net ...[more]