Regioselective gold-catalyzed oxidative C-N bond formation.

ABSTRACT: A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.

SUBMITTER: Marchetti L 

PROVIDER: S-EPMC4301077 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature