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Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes.

ABSTRACT: We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au-Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.

SUBMITTER: Ebule R

PROVIDER: S-EPMC5634393 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes.

Ebule Rene R Liang Shengzong S Hammond Gerald B GB Xu Bo B

ACS catalysis 20170907 10

We have developed a highly regioselective homogeneous gold(I)-catalyzed <i>anti</i>-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au-Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air. ...[more]

PMID: 29034119

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