Ontology highlight
ABSTRACT:
SUBMITTER: Sadek J
PROVIDER: S-EPMC7156456 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Sadek Jouliana J Wuo Michael G MG Rooklin David D Hauenstein Arthur A Hong Seong Ho SH Gautam Archana A Wu Hao H Zhang Yingkai Y Cesarman Ethel E Arora Paramjit S PS
Nature communications 20200414 1
Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this challenge. Various regulators are known to interact with different coiled coil regions of NEMO, but the topological complexity of this protein has limited inhibitor design. We undertook a comprehensive effort to block the interaction between vFLIP, a Kaposi's sarcoma herpesviral oncoprotein, a ...[more]