Ontology highlight
ABSTRACT:
SUBMITTER: Lundvig DM
PROVIDER: S-EPMC4302653 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Lundvig Ditte M S DM Scharstuhl Alwin A Cremers Niels A J NA Pennings Sebastiaan W C SW te Paske Jeroen J van Rheden René R van Run-van Breda Coby C Regan Raymond F RF Russel Frans G M FG Carels Carine E CE Maltha Jaap C JC Wagener Frank A D T G FA
Journal of cellular and molecular medicine 20140916 12
Impaired wound healing can lead to scarring, and aesthetical and functional problems. The cytoprotective haem oxygenase (HO) enzymes degrade haem into iron, biliverdin and carbon monoxide. HO-1 deficient mice suffer from chronic inflammatory stress and delayed cutaneous wound healing, while corneal wound healing in HO-2 deficient mice is impaired with exorbitant inflammation and absence of HO-1 expression. This study addresses the role of HO-2 in cutaneous excisional wound healing using HO-2 kno ...[more]