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Nuclear imaging modalities for cardiac amyloidosis.


ABSTRACT: Amyloidosis is a heterogeneous group of diseases characterized by localized or systemic deposition of insoluble extracellular fibrillary proteins in organs and tissues. Several types of amyloid can infiltrate the heart resulting in a restrictive cardiomyopathy, heart failure, and atrial and ventricular arrhythmias. Scintigraphy is a noninvasive method that may facilitate early diagnosis, distinguish various forms of cardiac amyloid, and may be useful in following disease burden. The amyloid-specific tracers presented in this article have been used with planar imaging and/or single-photon emission computed tomography. To date, there are no approved cardiac amyloid tracers although investigational tracers are currently under examination. This article serves to review the current nuclear imaging modalities available in the detection of cardiac amyloid.

SUBMITTER: Bokhari S 

PROVIDER: S-EPMC4302756 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Nuclear imaging modalities for cardiac amyloidosis.

Bokhari Sabahat S   Shahzad Reehan R   Castaño Adam A   Maurer Mathew S MS  

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20140201 1


Amyloidosis is a heterogeneous group of diseases characterized by localized or systemic deposition of insoluble extracellular fibrillary proteins in organs and tissues. Several types of amyloid can infiltrate the heart resulting in a restrictive cardiomyopathy, heart failure, and atrial and ventricular arrhythmias. Scintigraphy is a noninvasive method that may facilitate early diagnosis, distinguish various forms of cardiac amyloid, and may be useful in following disease burden. The amyloid-spec  ...[more]

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