Ontology highlight
ABSTRACT:
SUBMITTER: Dantas Machado AC
PROVIDER: S-EPMC4303714 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Dantas Machado Ana Carolina AC Zhou Tianyin T Rao Satyanarayan S Goel Pragya P Rastogi Chaitanya C Lazarovici Allan A Bussemaker Harmen J HJ Rohs Remo R
Briefings in functional genomics 20141014 1
Many anecdotal observations exist of a regulatory effect of DNA methylation on gene expression. However, in general, the underlying mechanisms of this effect are poorly understood. In this review, we summarize what is currently known about how this important, but mysterious, epigenetic mark impacts cellular functions. Cytosine methylation can abrogate or enhance interactions with DNA-binding proteins, or it may have no effect, depending on the context. Despite being only a small chemical change, ...[more]