Ontology highlight
ABSTRACT:
SUBMITTER: Bar-Shir A
PROVIDER: S-EPMC4304440 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bar-Shir Amnon A Yadav Nirbhay N NN Gilad Assaf A AA van Zijl Peter C M PC McMahon Michael T MT Bulte Jeff W M JW
Journal of the American Chemical Society 20141222 1
The local presence and concentration of metal ions in biological systems has been extensively studied ex vivo using fluorescent dyes. However, the detection of multiple metal ions in vivo remains a major challenge. We present a magnetic resonance imaging (MRI)-based method for noninvasive detection of specific ions that may be coexisting, using the tetrafluorinated derivative of the BAPTA (TF-BAPTA) chelate as a (19)F chelate analogue of existing optical dyes. Taking advantage of the difference ...[more]