Ontology highlight
ABSTRACT:
SUBMITTER: An S
PROVIDER: S-EPMC7038928 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
An Sanqi S Huang Wanxu W Huang Xiang X Cun Yixian Y Cheng Weisheng W Sun Xiang X Ren Zhijun Z Chen Yaxin Y Chen Wenfang W Wang Jinkai J
Nucleic acids research 20200201 4
N6-methyladenosine (m6A) is a reversible and dynamic RNA modification in eukaryotes. However, how cells establish cell-specific m6A methylomes is still poorly understood. Here, we developed a computational framework to systematically identify cell-specific trans regulators of m6A through integrating gene expressions, binding targets and binding motifs of large number of RNA binding proteins (RBPs) with a co-methylation network constructed using large-scale m6A methylomes across diverse cell stat ...[more]