Ontology highlight
ABSTRACT:
SUBMITTER: Fako VE
PROVIDER: S-EPMC4306520 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Fako Valerie E VE Wu Xi X Pflug Beth B Liu Jing-Yuan JY Zhang Jian-Ting JT
Journal of medicinal chemistry 20141229 2
Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of free fatty acids, is up-regulated in many cancers. FASN is essential for cancer cell survival and contributes to drug resistance and poor prognosis. However, it is not expressed in most nonlipogenic normal tissues. Thus, FASN is a desirable target for drug discovery. Although different FASN inhibitors have been identified, none has successfully moved into clinical use. In this study, using in silico screening of an FDA-a ...[more]