Ontology highlight
ABSTRACT:
SUBMITTER: Churamani D
PROVIDER: S-EPMC4313535 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Churamani Dev D Boulware Michael J MJ Ramakrishnan Latha L Geach Timothy J TJ Martin Andrew C R AC Vacquier Victor D VD Marchant Jonathan S JS Dale Leslie L Patel Sandip S
Cellular signalling 20080913 12
The sea urchin is an extensively used model system for the study of calcium signalling by the messenger molecules NAADP and cyclic ADP-ribose. Both are synthesized by ADP-ribosyl cyclases but our molecular understanding of these enzymes in the sea urchin is limited. We have recently reported the cloning of an extended family of sea urchin ADP-ribosyl cyclases and shown that one of these enzymes (SpARC1) is active within the endoplasmic reticulum lumen. These studies suggest that production of me ...[more]