Ontology highlight
ABSTRACT:
SUBMITTER: Papoff G
PROVIDER: S-EPMC4313936 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Papoff Giuliana G Trivieri Nadia N Marsilio Sonia S Crielesi Roberta R Lalli Cristiana C Castellani Loriana L Balog Edward M EM Ruberti Giovina G
PloS one 20150202 2
FADD (Fas-associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells. They are both involved in death receptors mediated signaling pathways and have been linked to the Toll-like receptor family and innate immunity. Here we identify and characterize by database search analysis, mutagenesis and calmodulin (CaM) pull-down assays a calcium-dependent CaM binding site in the α-helices 1-2 of TRADD deat ...[more]