Ontology highlight
ABSTRACT:
SUBMITTER: Lubker C
PROVIDER: S-EPMC4516931 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Lübker Carolin C Dove Stefan S Tang Wei-Jen WJ Urbauer Ramona J Bieber RJ Moskovitz Jackob J Urbauer Jeffrey L JL Seifert Roland R
Toxins 20150713 7
Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca2+-sensor calmodulin (CaM) leads to massive cAMP production resulting in edema. cAMP also inhibits the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, thus reducing production of reactive oxygen species (ROS) used for host defense in activated neutrophils and thereby facilitating bacterial growth. Methi ...[more]