Ontology highlight
ABSTRACT:
SUBMITTER: Boutant M
PROVIDER: S-EPMC4314542 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Boutant Marie M Joffraud Magali M Kulkarni Sameer S SS García-Casarrubios Ester E García-Roves Pablo M PM Ratajczak Joanna J Fernández-Marcos Pablo J PJ Valverde Angela M AM Serrano Manuel M Cantó Carles C
Molecular metabolism 20141218 2
<h4>Objective</h4>SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets, studies aiming to understand the etiology of such benefits are scarce. Here, we aimed to identify the key tissues and mechanisms implicated in the beneficial effects of SIRT1 on glucose homeostasis.<h4>Methods</h4>We have used a mouse ...[more]