Ontology highlight
ABSTRACT:
SUBMITTER: Winn NC
PROVIDER: S-EPMC6702635 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Winn Nathan C NC Acin-Perez Rebeca R Woodford Makenzie L ML Hansen Sarah A SA Haney Megan M MM Ayedun Lolade A LA Rector R Scott RS Vieira-Potter Victoria J VJ Shirihai Orian S OS Sacks Harold S HS Kanaley Jill A JA Padilla Jaume J
Diabetes 20190312 9
The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models, though much of the evidence supporting this premise is from thermostressed rodents. Determination of whether modulation of the BAT morphology/function drives changes in glucoregulation at thermoneutrality requires further investigation. We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme <i>Pnpla2</i>, ...[more]