Ontology highlight
ABSTRACT:
SUBMITTER: Brett ZH
PROVIDER: S-EPMC4317330 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Brett Zoe H ZH Sheridan Margaret M Humphreys Kate K Smyke Anna A Gleason Mary Margaret MM Fox Nathan N Zeanah Charles C Nelson Charles C Drury Stacy S
International journal of behavioral development 20150301 2
An individual's neurodevelopmental and cognitive sequelae to negative early experiences may, in part, be explained by genetic susceptibility. We examined whether extreme differences in the early caregiving environment, defined as exposure to severe psychosocial deprivation associated with institutional care compared to normative rearing, interacted with a biologically informed genoset comprising <i>BDNF</i> (rs6265), <i>COMT</i> (rs4680), and <i>SIRT1</i> (rs3758391) to predict distinct outcomes ...[more]