Recent insights into the mode of action of memantine and ketamine.
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ABSTRACT:
SUBMITTER: Johnson JW
PROVIDER: S-EPMC4318755 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Recent insights into the mode of action of memantine and ketamine.
Johnson Jon W JW Glasgow Nathan G NG Povysheva Nadezhda V NV
Current opinion in pharmacology 20141202
The clinical benefits of the glutamate receptor antagonists memantine and ketamine have helped sustain optimism that glutamate receptors represent viable targets for development of therapeutic drugs. Both memantine and ketamine antagonize N-methyl-D-aspartate receptors (NMDARs), a glutamate receptor subfamily, by blocking the receptor-associated ion channel. Although many of the basic characteristics of NMDAR inhibition by memantine and ketamine appear similar, their effects on humans and to a l ...[more]
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