Ontology highlight
ABSTRACT:
SUBMITTER: Ito S
PROVIDER: S-EPMC4321179 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Ito Sachiko S Tanaka Yuriko Y Oshino Reina R Aiba Keiko K Thanasegaran Suganya S Nishio Naomi N Isobe Ken-ichi K
Scientific reports 20150209
Autophagy is a common physiological function in all eukaryotes. The process is induced by depletion of nutrients including amino acids. GADD34 is expressed following DNA damage, ER stresses and amino acid deprivation. Here, we investigated the effects of GADD34 on autophagy and cell activation in macrophages. The deprivation of tyrosine and cysteine markedly induced the expression of GADD34 in macrophages. LPS stimulation combined with tyrosine/cysteine-deprivation initially activated macrophage ...[more]