Ontology highlight
ABSTRACT:
SUBMITTER: Ratto-Kim S
PROVIDER: S-EPMC4321833 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150209 2
We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed Env-specific T cell lines established from RV144 vaccinees were used to determine the fine epitope mapping of the V2 and C1 responses and the HLA class II restriction. Data showed that there are two CD4+ epitopes contained within the V2 loop: one encompassing the α4β7 integrin binding site (AA179-181) and the other nested between two previo ...[more]